Profiles in Basal Forebrain Non-cholinergic Neurons

نویسندگان

  • Saak V. Ovsepian
  • Oliver J. Dolly
  • Laszlo Zaborszky
چکیده

2 Intrinsic Voltage Dynamics Govern the Diversity of Spontaneous Firing 3 Profiles in Basal Forebrain Non-cholinergic Neurons 4 5 6 Saak V. Ovsepian, Oliver J. Dolly and Laszlo Zaborszky 7 8 (1) Centre for Molecular and Behavioral Neuroscience, Rutgers, The State University of 9 New Jersey, 197 University Avenue, Newark, NJ 07102, USA; (2) International Centre 10 for Neurotherapeutics, Research and Engineering Building, Glasnevin, Dublin City 11 University, Dublin 9, Rep. of Ireland. 12 13 Corresponding author: Dr. Saak V. Ovsepian, International Centre for Neurotherapeutics, 14 Research and Engineering Building, Glasnevin, Dublin City University, Dublin 9, Rep. of 15 Ireland. 16 17 Phone: (353)-1-7007361 18 Email: [email protected] 19 20 21 22 23 Articles in PresS. J Neurophysiol (April 11, 2012). doi:10.1152/jn.00642.2011

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Physiological Properties of Cholinergic and Non-Cholinergic Magnocellular Neurons in Acute Slices from Adult Mouse Nucleus Basalis

BACKGROUND The basal forebrain is a series of nuclei that provides cholinergic input to much of the forebrain. The most posterior of these nuclei, nucleus basalis, provides cholinergic drive to neocortex and is involved in arousal and attention. The physiological properties of neurons in anterior basal forebrain nuclei, including medial septum, the diagonal band of Broca and substantia innomina...

متن کامل

Local synaptic connections of basal forebrain neurons.

Single, biocytin filled neurons in combination with immunocytochemistry and retrograde tracing as well as material with traditional double-immunolabeling were used at the light and electron microscopic levels to study the neural circuitry within the basal forebrain. Cholinergic neurons projecting to the frontal cortex exhibited extensive local collaterals terminating on non-cholinergic, (possib...

متن کامل

Treatment of beta amyloid 1–42 (Aβ1–42)-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo

In Alzheimer's disease (AD), there is a loss in cholinergic innervation targets of basal forebrain which has been implicated in substantial cognitive decline. Amyloid beta peptide (Aβ(1-42)) accumulates in AD that is highly toxic for basal forebrain cholinergic (BFC) neurons. Although the gonadal steroid estradiol is neuroprotective, the administration is associated with risk of off-target effe...

متن کامل

Dissociation between the attentional functions mediated via basal forebrain cholinergic and GABAergic neurons.

The role of basal forebrain corticopetal cholinergic projections in attentional functions has been extensively investigated. For example, 192 IgG-saporin-induced loss of cortical cholinergic inputs was repeatedly demonstrated to result in a selective impairment in the ability of rats to detect signals in a task designed to assess sustained attention performance. The loss of cortical cholinergic...

متن کامل

Non-cholinergic basal forebrain neurons project to the contralateral basal forebrain in the rat.

Following injections of wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) or the fluorescent tracer fluoro-gold into the magnocellular preoptic area and the horizontal limb of the diagonal band, retrogradely labelled neurons were found in the homotopic region of the contralateral basal forebrain. Labelled fibers apparently arising from these neurons travelled in the stria medull...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012